rth if you have have rickets and other diseases that affect bone structure.CausesSkeletal limb abnormalities may be due to:CancerGenetic diseases and chromosomal abnormalities, including Marfan syndrome, Down syndrome, Apert syndrome, Basal cell nevus syndromeImproper position in the wombInfections during pregnancyInjury during birthMalnutritionMetabolic disordersPregnancy problems, including limb