#STR00041##The butynol may be converted to amide 10 by a number of different methods, two of which are referred to as Method A and Method B:##STR00042####STR00043##In each of Methods A and B, P is a protecting group and X is a leaving group and is selected from the group consisting of Cl, Br, I, and heterocyclic rings, L is a ligand and is selected from PR'.sub.3 wherein R' is selected from the gr