These results suggested that activation of p38 is downstream of zinc release and 12-LOX activation induced by peroxynitrite.DiscussionGeneration of peroxynitrite and disruption of zinc homeostasis have recently been considered to be the two major components of neuronal injury in stroke and neurodegenerative diseases, including Alzheimer???s disease and ALS (Heales et al., 1999; Weiss et al., 2000)