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| - These problems include dermal changes (pigmentation, hyperkeratosis, and ulceration), gastrointestinal effects (stomach pain, nausea, vomiting, and diarrhea), neurological damage, cardiovascular problems (high blood pressure, heart attack, and stroke), various types of cancer (skin, bladder, lung, kidney, and other organs), and respiratory, pulmonary, hematological, hepatic, renal, developmental,
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