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| - The variant TNFSF proteins are major effectors in the pathogenesis of immune-regulated diseases. [0187] In a preferred embodiment, the variant TNFSF protein is used to treat for example, congestive heart failure (CHF), vasculitis, rosecea, acne, excema, myocarditis and other conditions of the myocardium, systemic lupus erythematosus, diabetes, spondylopathies, synovial fibroblasts, and bone marrow
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