Chronic wounds may be infected by bacteria such as Streptococcus pyogenes, Enterococcus faecalis, Staphylococcus aureus/MRSA [9], Pseudomonas aeruginosa, Enterobacter aerogenes, and Escherichia coli, while fungi and viruses may also cause skin and wound infections [10].Many bacteria have developed resistance due to the abuse use of antibiotics, while the existing drugs have also caused serious adv