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  • The methods of the invention further can be used to treat headache pain; muscle pain; and the pain associated with substance abuse or withdrawal and other types of pain of known or unknown etiology. [0062] Several of the methods of the invention rely, in part, on an ?????-adrenergic agonist,??? which, as used herein, is a term which means a compound having greater than 25% efficacy relative to bri
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