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  • The mutations of the TTR gene causes the accumulation of abnormal amyloid proteins that damage body organs and tissue, including peripheral nerves and heart, resulting in peripheral sensory neuropathy, autonomic neuropathy, and/or cardiomyopathy - morbid conditions with significant mortality. familial amyloidotic polyneuropathy (FAP) patients have a life expectancy of 5 to 15 years from symptom on
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