The method as defined in claim 1 wherein the MTP inhibitor has the structure ##STR65## wherein Z is a bond, O or S; x1 and x2 are independently selected from H or halo;x is an integer from 2 to 6;R5 is heteroaryl, aryl, heterocycloalkyl or cycloalkyl, each R5 group being optionally substituted with 1, 2, 3 or 4 substituents which may be the same or different; the piperidine N-oxide thereof, and ph