These two approaches are illustrated schematically and discussed in detail below. ##STR8##In Scheme I, R.sup.1 and R.sup.2 are as previously defined under formula III. Pradimicin aglycone esters of formula IX are generally insoluble or poorly soluble in organic solvents such as methylene chloride, chloroform, dichloroethane, anddioxane making it inconvenient as starting material for direct glycosi