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  • The Miles assay for vascular permeability (Miles and Miles, J. Physiol. 118:228-257 (1952)) has been adapted to athymic mice in order to evaluate the ability of the compounds of the present invention to inhibit VEGF-induced vascular permeability in vivo.General ProcedureTest compound or vehicle is administered prior to (typically it is 4 hours prior) to VEGF injection. 100 .mu.l of 0.5% Evan's blu
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