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  • This work explored the relationships among inflammation, hypoxia and sleep in the period of adaptation and examined a novel mechanism that might explain the harmful effects of altitude on sleep, involving increased Interleukin-1 beta (IL-1??), Interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-??) production from several tissues and cells, such as leukocytes and cells from skeletal muscle
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