The method of claim 13, wherein said terminal-phosphate-labeled nucleotide may be represented by formula: wherein P=phosphate (PO3) and derivatives thereof, n is 2 or greater; Y is an oxygen or sulfur atom; B is a nitrogen-containing heterocyclic base; S is an acyclic moiety, carbocyclic moiety or sugar moiety; P-L is a phosphorylated label with a linker between L and P, wherein L is a label conta