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  • Therefore, the frequency of monitoring may be determined by physician discretion.4) Inform patients to contact physician immediately if they develop symptoms or signs of hepatotoxicity such as fever, malaise, nausea, vomiting, abdominal distress, dark urine, clay colored stools, or icterus. 5) If a patient does have clinical and/or laboratory evidence of hepatotoxicity (e.g. transaminases >5X uppe
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