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  • The difficulty with devices such as that shown in FIG. 1, however, arises from the fact that the occlusive layer 4, although necessary to maintain the medicament or other active agent from escaping outwardly, i.e., in order to ensure that all of the drug is available for transdermal application, will also be occlusive for water vapor, which may thus build up within occlusive layer 4, i.e., between
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