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  • Thus, in some embodiments, an effective amount of a TLR agonist is an amount that is effective to increase MMPs (e.g., MMP3, MMP8, MMP9, MMP12, and MMP13) mRNA and/or enzyme levels in lung tissue by at least about 10%, at least about 20%, at least about 25%, at least about 30%, at least about 40%, at least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, a
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