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  • These results uncover what we believe is a novel and critical role for cardiac neural crest in the formation of the semilunar valves and illustrate the importance of coordinate tissue-tissue interactions during cardiac development.ResultsLoss of Pax3 results in abnormal semilunar valve morphology.Pax3 is expressed by premigratory neural crest, and Pax3 mutants display well-characterized defects of
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