When Ar??? is substituted phenyl, typically it is substituted with 1 to 3 substituents independently selected from halo, methyl, O-methyl, S-methyl or N(CH3)2, morpholino, or 3,4 dioxymethylene.Compounds of the invention, including novel compounds of the invention, can also be used in the methods described herein.The compounds and salts thereof described herein also include their corresponding hyd