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  • This step is typically conducted in an organic solvent, such as diethyl ether, at a temperature which is within the range of about ???20??? C. to about 60??? C., and is preferably conducted at a temperature which is within the range of 0??? C. to about 30??? C. The same product above can be made in aqueous sodium hydroxide solution containing one mole of the cyclic amine followed by dropwise addit
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