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  • The reaction is conveniently carried out if an inert solvent, such as a cyclic ether, for example tetrahydrofuran or dioxane, preferably dioxane at a temperature of from 40?? C. to the reflux temperature of the mixture preferably at about 70?? C. [0088] All of the compounds of Formula I which include the compounds set forth in the Examples, activated glucokinase in vitro by the procedure of Exampl
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