Chronic rhinosinusitis (CRS), a common disease associated with persistent inflammation of the nasal and paranasal sinuses, is a public health problem resulting in a socioeconomic burden throughout the world.1, 2 CRS is commonly classified into two groups, CRSsNP and CRSwNP. Considerable heterogeneity within CRSwNP has been recognized and there are geographic differences in the condition.3, 4 Tissu