The use of a 15-keto-prostaglandin compound of formula (i) for the manufacture of a medicament for suppressing increased portal vein pressure, wherein formula (i) is:FORMULA/TABLE/GRAPHICwherein X and Y are hydrogen, hydroxy, halogen, straight or branched C1-6 alkyl, hydroxyl straight or branched (C1-6) alkyl, or oxo, with the proviso that at least one of X and Y is a group other than hydrogen, an