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  • In addition, other factors such as the strength, duration and timing of interaction between TCR and peptide-MHC, the induction of pro- or anti-inflammatory environments, the precursor frequency of antigen-specific CD8 T cells, the cellular tropism of a pathogen and its persistence in the host, are all influencing the composition and maintenance of memory T cell compartment [31,32,33,34,35,36].
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