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  • All metabolic disorders, including diabetes mellitus, insulin resistance, and the metabolic syndrome, should be aggressively managed before HCV treatment is initiated because interferon can exacerbate these medical conditions.[35] Two classes of drugs are effective at correcting insulin resistance???biguanides (eg, metformin) and thiazolidinediones (eg, rosiglitazone and pioglitazone)???but eviden
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