Outcome: In the nine studies included, there was a non-significant increased pooled risk for non-fatal myocardial infarctions (MI) and coronary heart disease (CHD) death of 13% for n-6 Poly unsaturated fats (PUFA) intake (RR=1.13, CI: 0.84, 1.53) and a decreased risk of 22% (RR=0.78, CI: 0.65, 0.93) for mixed n-3/n-6 PUFA diets as compared to the control groups.Overview: Studies were included if P