Such sprays may be prepared from microspheres of a wide array of sizes, including for example, from 0.1 ??m to 3 ??m, from 10 ??m to 30 ??m, and from 30 ??m to 100 ??m (see Example 8). [0121] Anti-angiogenic compositions may also be prepared, given the disclosure provided herein, for a variety of other applications.