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  • Before getting into details of their work, a few words on the role of PPARs in NAFLD/NASH are in order.PPARs are lipid-activated nuclear receptors highly conserved in mammals that, upon activation by the appropriate ligand, control complex networks of target genes involved in a myriad of processes, including energy homeostasis, inflammatory response, and lipid and carbohydrate metabolism.[6] Recep
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