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  • ene, and R3 is imidazolyl that is bonded via a ring carbon or ring nitrogen atom and is unsubstituted or substituted by lower alkyl, especially C1 -C4 alkyl, such as methyl, for example imidazol-1-yl, imidazol-5-yl, 1-methylimidazol-2-yl or 4-methylimidazol-5-yl, or is pyridyl, such as 2- or 3-pyridyl, or wherein R1 is hydroxy and R2 is --A--R3 in which A is as defined above and R3 is amino, di-C1
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