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  • en thought to be characteristic of SjS. There is evidence that the infiltrates produce proinflammatory cytokines, including interleukin (IL)-1, ???6, ???12, and ???18; interferon (IFN)-??; and tumor necrosis factor (TNF)-??. 4 5 6 7 8 However, in addition to the regulatory cytokines IL-10 and transforming growth factor (TGF)-??1, the Th-2 cytokine IL-4 is detected in some samples, 9 10 where it ha
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