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  • Weight gain most frequently occurs with valproate use in about 40% of women,71 although it can also occur with the use of gabapentin and carbamazepine.60 Alternatively, topiramate, zonisamide, and felbamate may cause weight loss.72 Excessive weight is a known primary risk factor for systemic morbidity and mortality, including hypertension, type 2 diabetes mellitus, coronary artery disease, and str
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