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  • Reaction of cysteine or an ester of cysteine (compound 8, Scheme 6), where R1 is hydrogen, methyl, ethyl, t-butyl, benzyl or other carboxyl protecting groups with a species X-CKH2 CO2 R2, where X is a leaving group as defined above and R2 is independently hydrogen, methyl, ethyl, t-butyl, benzyl or other carboxyl protecting groups, in the presence of a base such as sodium bicarbonate, triethylamin
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