Selective modulators may include, for example, antibodies and other proteins or peptides that-specifically bind to an hPARP2 polypeptide or an hPARP2-encoding polynucleotide, oligonucleotides that specifically bind to hPARP2 polypeptides or hPARP2-encoding polynucleotides, and other non-peptide compounds (e.g., isolated or synthetic organic molecules) that specifically react with hPARP2 polypeptid