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  • Levels of circulating proinflammatory cytokines and chemokines, such as tumor necrosis factor (TNF)-??, interleukin (IL)-6, and IL-8, are increased in patients with OSAS.8???9 In addition, OSAS induces the activation of adhesion molecules, including intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, and L-selectin.10Furthermore, platelet aggregation and activation
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