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  • Method A: ##STR9## Compounds of formula Ia and Ib, wherein Ar1, Ar2, Ar3, X, Y, Z, R, R1, R2, R3, m, n, p, q and r are as defined above, can be prepared by treatment of an ester of formula III, wherein R10 is lower alkyl such as ethyl or a chiral moiety such as menthyl or 10-(diisopropylsulfonamido)isobomyl, and the remaining variables are as defined above, with a strong base such as lithium diiso
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