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  • Pathological similarities to the animal model for Th1-mediated brain inflammation, experimental autoimmune encephalomyelitis (EAE), have suggested that MS is an autoimmune disorder caused by myelin-specific CD4+ T cells of the Th1 (Lassmann and Ransohoff, 2004; Sospedra and Martin, 2005) and/or Th17 type (Gutcher et al., 2006; Weaver et al., 2006).
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