Reply Temple says: April 11, 2012 at 9:54 pm Central nervous system and/or respiratory-depressant effects may be additively or synergistically increased in patients who combine drugs such as Ambien and Oxycodone, which cause these effects, especially in elderly or debilitated patients??? More:http://www.chacha.com/question/how-dangerous-is-it-to-mix-ambien-and-oxycodon