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  • In the bone microenvironment, RANKL and its soluble form (sRANKL) are expressed on the surface of osteoclasts, B cells, activated T cells, and stromal cells, while OPG (a decoy receptor for RANK) is produced by different tissues and cell types including osteoblasts, B cells, dendritic cells, and bone narrow stromal cells [56???59, 61].
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