Homocysteine PF?? (Protection Factors) contains methyl group (CH3) donors from Methyl B12, TMG and Folic Acid, plus vitamin B6 for additional reduction of homocysteine.* Methyl groups convert homocysteine, a toxic amino acid, into methionine, which is an essential amino acid.* Methylation is inhibited by such factors as poor diet, smoking and genetic predisposition.