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  • It is apparent that diet and environmental factors such as smoking play a role in the course of the disease, but there is now strong evidence for a hereditable component.21-23 Recently, definitive gene mutations have been identified as common to a large number of AMD sufferers: complement factor-H,24,25 with modifiers (Factor B),26 HEMICENTIN-1,(27) fibulin, and ABCA4.
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