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  • Carboxylic acids of formula (III) may be converted to their activated derivatives using methods described herein or according to methods generally known in the art, e.g., a carboxylic acid of formula (III) may be treated with a chlorinating agent such as thionyl chloride or oxalyl chloride to afford a corresponding acid chloride thereof, or by the treatment with a coupling agent such as EDCl or HO
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