Jaundice there is excess bilirubin in the blood leading to distribution of bilirubin to the skin, mucous membranes and other body fluids and tissues, giving them yellowish discoloration occurs when bilirubin level is > 2.5 mg/dl Bilirubin in the skin causes pruritus (itching) Causes : intrahepatic cholestasis (stasis of bile w/in the liver) due to drug interactions extrahepatic abstruction ??? obs