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  • Base is a purine base; R1 is OR3, N3, CN, CF3, lower alkyl, amino, loweralkylamino, or di(lower)alkylamino; R2 is H, monophosphate, diphosphate, triphosphate, a stabilized phosphate prodrug, acyl, phosphate, or phosphonate, a lipid or an amino acid; and R3 is acyl, alkyl, phosphate, or other pharmaceutically acceptable leaving group which when administered in vivo, is capable of being cleaved to t
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