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  • Patients should therefore be educated on signs and symptoms such as muscle weakness, fatigue, shortness of breath, and abdominal pain.11 Adefovir: Adefovir dipivoxil is an NA that is active against wild-type HBV and lamivudine-resistant HBV. However, its anti-HBV activity is less potent than lamivudine???s, so it is not a recommended first-line therapy.2 In patients with lamivudine-resistant HBV,
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