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  • Lactulose was used 50 years ago as a prebiotic formula supplement to increase the number of Lactobacillus strains in infants??? intestines [25].Fructooligosaccharides, inulin, oligofructose, lactulose, and galactooligosaccharides have been identified as prebiotics due to characteristics such as resistance to gastric acidity and hydrolysis by mammalian enzymes and they are fermented by gastrointest
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