atom in the 9 position, or is an ??-hydroxyl group when R3 is a ??-hydroxyl group, R5 is a hydrogen atom, a hydroxyl group, a carbonyl oxygen, or a hydroxyl and methyl pair, R6 is a hydrogen atom or a methyl group, R7 is a hydrogen atom or a methyl group, R8 is a hydrogen atom or a hydroxyl group, and R9 is a hydroxyl group or an alkyl group; and an effective amount of a pharmaceutically acceptabl