guide-wire through which a biologically active agent is delivered at one or more of locations A, B and C. [0049]FIG. 20 is a side view of a gripper device to facilitate removal of an embolism protection device. [0050]FIG. 21 is a photomicrographs of a PET fiber. [0051]FIG. 22 is a photomicrograph of a PET fiber with grafted with a polyacrylamide hydrogel. [0052]FIG. 23 is a plot of the standard c