Preparation of 6-O-Monotosyl-6-deoxy-??-cyclodextrin (??-CDOTs) (1) and Structural Characterization by 1H NMR??-CDOTs is the most important intermediate product in order to further functionalize the primary hydroxyl groups (C6) of ??-CD, since tosylate is a good leaving group and can be easily substituted by other nucleophiles.