Synthetic materials (such as calcium sulfates or calcium phosphates) have been processed into several shapes (tablets, beads, pellets, sticks, sheets, and blocks) and may contain additives such as antibiotics (e.g., Osteoset???-T (Wright Medical Technology; Arlington, Tenn.)) or bioactive agents (e.g., Rhakoss??? (Orthovita???; Malvern, Pa.)).