A method of treatment or alleviation of a disease or a disorder or a condition of a living animal body, including a human, which is elected from the group consisting ofasthma, cystic fibrosis, chronic obstructive pulmonary disease and rhinorrhea, convulsions, bladder spasms and urinary incontinence, through the modulation of of SK.sub.Ca, IK.sub.Ca and/or BK.sub.Ca channels, which comprises the st