Inhibition of advanced glycation end-product formation on eye lens protein by rutin - Br J Nutr. 2011 Aug 25:1-9 - Formation of advanced glycation end products (AGE) plays a key role in the several pathophysiologies associated with ageing and diabetes, such as arthritis, atherosclerosis, chronic renal insufficiency, Alzheimer's disease, nephropathy, neuropathy and cataract.